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2005•Journal of Medical ForumRequires access

Determination of Content of Ferulic Acid by HPLC

Xiaojing Shen

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Abstract

Objective To establish a RP-HPLC method for determinating content of ferulic acid in Fuketiaojing tablet. Methods The content was determined by HPLC. The analysis was carried on C18 column, the mobile phase was consisted of methanol- 0.1% phosphoric acid(30∶70)with the flow rate at 1.0ml/min and the UV detection wavelength was at 313 nm. Results The linear regression for Fuketiaojing tablet was over the range of 0.0388 ~ 0.3104 μg (r= 0.9999 ). The average recovery rate of Fuketiaojing tablet was 97.16% (RSD = 0.17% ,n=5). Conclusion This method was sensitive, accurate, reproducible and exclusive.

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What this paper is about

Objective To establish a RP-HPLC method for determinating content of ferulic acid in Fuketiaojing tablet. Methods The content was determined by HPLC. The analysis was carried on C18 column, the mobile phase was consisted of methanol- 0.1% phosphoric acid(30∶70)with the flow rate at 1.0ml/min and the UV detection wavelength was at 313 nm. Results The linear regression for Fuketiaojing tablet was over the range of 0.0388 ~ 0.3104 μg (r= 0.9999 ). The average recovery rate of Fuketiaojing tablet was 97.16% (RSD = 0.17% ,n=5). Conclusion This method was sensitive, accurate, reproducible and exclusive.

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Available abstract

Objective To establish a RP-HPLC method for determinating content of ferulic acid in Fuketiaojing tablet. Methods The content was determined by HPLC. The analysis was carried on C18 column, the mobile phase was consisted of methanol- 0.1% phosphoric acid(30∶70)with the flow rate at 1.0ml/min and the UV detection wavelength was at 313 nm. Results The linear regression for Fuketiaojing tablet was over the range of 0.0388 ~ 0.3104 μg (r= 0.9999 ). The average recovery rate of Fuketiaojing tablet was 97.16% (RSD = 0.17% ,n=5). Conclusion This method was sensitive, accurate, reproducible and exclusive.

Key concepts: Chromatography, Ferulic acid, Phosphoric acid, High-performance liquid chromatography, Chemistry, Content determination, Linear range, Linear relationship

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