2013•Anhui nongye kexueRequires access
Anti-oxidative Effects of Taohe Chengqi Decoction on Liver,Kidney and Heart of STZ-induced Diabetic Rats
Jin Li
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Abstract
[Objective]To study the anti-oxidative activity of Taohe Chengqi Decoction on liver,kidney and heart of diabetic rats.[Method] Diabetic models were established by tail vein injection of small dose streptozotocin(45 mg/kg),the three groups divided:control group,diabetes group,treatment group(Taohe Chengqi decoction 10 ml/mg·d).At the 56 th day,left kidney index,right kidney index and liver index were detected,the levels of CAT,MDA,GSH-Px and SOD in liver,kidney and heart homogenate were detected.[Result] The body weight of treatment group were significantly higher with diabetes group(P 0.01),left kidney index and right kidney index of diabetes group were no significant change,liver index very significantly reduced compared with diabetes group(P 0.01);SOD and CAT activities in liver were significantly higher in treatment group than those in diabetes group(P 0.05);GSH-Px activities in heart were significantly higher than diabetes group(P 0.05);level of MDA were significantly lower in liver,kidney and heart tissue in treatment group than diabetes group(P 0.05).[Conclusion]Taohe Chengqi Decoction could improve diabetic rat liver,kidney and heart tissue antioxidant capacity,reduce oxidative damage through oxygen free radical scavenging and anti-lipid peroxidation.