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2007•Chinese Journal of Clinical Obstetrics and GynecologyRequires access

The relationship between insulin resistance and macrosomia in pregnant women with abnormal glucose metabolism

Yanfeng Zhan

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Abstract

Objective To study insulin resistance and islet β cell function in women with gestational impaired glucose tolerance and diabetes mellitus, and to investigate the relationship between insulin resistance and macrosomia.Methods In 35 GIGT women and 12 GDM women, fasting blood glucose and insulin levels were measured, insulin resistance index(HOMA-IR) and βcell function index(HBCI) calculated by HOMA model.Results there was no difference in HBCI in the two groups, but significant difference in HOMA-IR; HOMA IR in the GDM women was higher than in the GIGT group. There was no significant correlation between HOMA-IR and macrosomia.Conclusion Women with GDM have stronger IR compared with GIGT women, and no significant difference was found between HOMA-R and macrosomia.

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What this paper is about

Objective To study insulin resistance and islet β cell function in women with gestational impaired glucose tolerance and diabetes mellitus, and to investigate the relationship between insulin resistance and macrosomia.Methods In 35 GIGT women and 12 GDM women, fasting blood glucose and insulin levels were measured, insulin resistance index(HOMA-IR) and βcell function index(HBCI) calculated by HOMA model.Results there was no difference in HBCI in the two groups, but significant difference in HOMA-IR; HOMA IR in the GDM women was higher than in the GIGT group. There was no significant correlation between HOMA-IR and macrosomia.Conclusion Women with GDM have stronger IR compared with GIGT women, and no significant difference was found between HOMA-R and macrosomia.

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Available abstract

Objective To study insulin resistance and islet β cell function in women with gestational impaired glucose tolerance and diabetes mellitus, and to investigate the relationship between insulin resistance and macrosomia.Methods In 35 GIGT women and 12 GDM women, fasting blood glucose and insulin levels were measured, insulin resistance index(HOMA-IR) and βcell function index(HBCI) calculated by HOMA model.Results there was no difference in HBCI in the two groups, but significant difference in HOMA-IR; HOMA IR in the GDM women was higher than in the GIGT group. There was no significant correlation between HOMA-IR and macrosomia.Conclusion Women with GDM have stronger IR compared with GIGT women, and no significant difference was found between HOMA-R and macrosomia.

Key concepts: Medicine, Insulin resistance, Gestational diabetes, Internal medicine, Endocrinology, Insulin, Impaired glucose tolerance, Significant difference

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