2011•Liaoning Zhongyiyao Daxue xuebaoRequires access

Establishment of Models of Type 2 Diabetes Dysimmunity Induced by Streptozotocin in Rats

Liang Zhang

Abstract

Objective:To establish an animal model similar to human Type 2 diabetes dysimmunity.Methods:Male SD grown-up rats were fed with high-sugar and high-fat feeds to induce the insulin resistance and given lumbar injection of small dosage STZ 35mg/kg,and fed with general feeds for a month Models of Type 2 diabetes dysimmunity were established.Results:Blood sugar of rats in experimental group increased and their sensitivity to insulin dropped,fasting insulin dropped,IL-6 increased,IL-2 dropped,biochemistry target confirmed that models was successfully made.Conclusion:Models of Type 2 diabetes dysimmunity in rats became ideal animal models to study and treat human Type 2 diabetes dysimmunity.

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Key concepts: Medicine, Type 2 diabetes, Streptozotocin, Diabetes mellitus, Insulin resistance, Blood sugar, Animal model, Insulin