Preparation of diabetes rat model induced by streptozotocin

Objective To establisk approriate method of diabetes rats model.Methods to establish type 1 diabetic rats model an animal Eight-week-old male Sprague-Dawley rats were intraperitionedl injected by a streptozotocin.Results Three days after injetion,the blood glucose of diabetes group were higher than 16.7 mmol/L.During the 8 weeks observation,the blood glucose values are always in the early hyperglycemia level fluctuation.Morphological investigation on pancreas showed the reduction of islets,loss of B cells in diabetes group.Conclusion The present experiment provided a type 1 diabetes rat model.