2009•Journal of clinical and experimental medicineRequires access
Type 2 diabetes rat model and its verification
Liang Zhi-qun
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Abstract
Objective Preparation of a disease similar to human type 2 diabetes animal model.Methods Male SD adult rats fed high-fat high-sugar a month,induced insulin resistance,given low-dose streptozotocin(STZ,25 mg/kg,intraperitoneal injection),set up in type 2 diabetic rat model.Results Test group of rats increased blood glucose,insulin sensitivity decreased,from the biochemical indices and morphology confirmed the successful model.Conclusion The experimental rat model of type 2 diabetes model successfully,it has moderately high blood sugar,insulin resistance,the success rate is high,are of human type 2 diabetes and its drug research ideal animal model.