Experimental study on the effect of adenosine disodium triphosphate on myocardial infarction rats

Objective To investigate the effect of adenosine disodium triphosphate( ADT) on myocardial infarction in rats. Methods The acute myocardial infarction rat model was induced by ligation of the left anterior descending coronary artery. The model rats were divided into five groups randomly: model group,ADT 1,2,4 mg·( kg·d)- 1and enalaprilat 10 mg·( kg·d)- 1,and the other 8 rats received sham surgery.The effect of ADT on myocardial infarction rats included left ventricular of configuration,the degree of myocardial hypertrophy and pulmonary edema,scope of myocardial infarction and myocardial remodeling were determined by color Doppler echocardiography,hemodynamic,heart weight,lung water content and the content of collagen type Ⅰand Ⅲ after continuous dosing for 30 days. Results Compared with model,ADT can improve left ventricular function of myocardial infarction rats,improve significantly left ventricular ejection fraction significantly,reduce left ventricular end- diastolic pressure and cavity size,the lung water content and the range of myocardial infarction,inhibit ventricular remodeling,etc. Conclusion ADT can improve the cardiac function after myocardial infarction in rats.