Protective effect of aspirin on experimental myocardial fibrosis induced by acute myocardial infarction through the ligation coronary artery in rats

OBJECTIVE To investigate the protective effect of aspirin on experimental myocardial fibrosis induced by acute cardiac infarction through the ligation of coronary artery in rats.METHODS The rats were randomly allotted to 3 groups as follows: sham operated group,model group and the aspirin group(the coronary artery was ligatied +30 mg·kg-1 aspirin).The animals were lived four or eight weeks after operation.The cardiac infarction was reproduced by ligating rat coronary artery.Four and eight weeks after the ligation of the coronary in rats,the following indexes were detected,hemodynamics including(left ventricular end-diastolic pressure,left ventricular systolic pressure,left ventricular mean pressure,maximum rate of left ventricular contraction,and left ventricular maximum rate of diastolic),cardiac remodeling indexes including(anterior left ventricular,left ventricular internal diameter,heart-long axis).And then the gross anatomy observation and histopathologic changes were recorded.RESULTS After four and eight weeks,the myocardial fibrosis was reproduced according to gross anatomy,and histopathologic examination.Ventricular systolic and diastolic dysfunctions and increasing of reconstruction indexes were observed as well.There were significant ameliorations of the indexes after the rats were treated with aspirin.CONCLUSION Aspirin can ameliorate experimental myocardial fibrosis induced by acute cardiac infarction.