2013•Chinese Journal of Hospital PharmacyRequires access

The improvement effect of Danhong injection on the cardiac function and left ventricular remodeling in myocardial infarction rats

Yuxin Wang

Abstract

OBJECTIVE To explore the improving effect of Danhong injection(DHI)on the cardiac function and left ventricular remodeling in myocardial infarction rats.METHODS Coronary artery ligation(CAL) was used to induce an in vivo model of myocardial infarction(MI).The experiment observed the influences of DHI on the anatomy indicators of heart and lung,ventricular scar area,left ventricular hemodynamics,myocardial pathological indicators and the levels of apoptotic genes.RESULTS 12 consecutive weeks' treatment of DHI after myocardial infarction could reduce the ratio of HW/BW and WLW/BW,left ventricular end-diastolic pressure,the diameter of cardiomyocyte and collagen volume fraction(P0.05),and increase the maximum rate of change of left ventricular pressure(P0.05),while caused no changes on the ventricular scar area and the apoptosis.CONCLUSION Danhong injection can attenuate the deterioration of cardiac function and ventricular remodeling(except the apoptosis) in the myocardial infarction rats.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Cardiology, Myocardial infarction, Ventricular remodeling, Internal medicine, Medicine, Cardiac function curve, Infarction, Ligation