Optimization of Extraction Process for Xifeng Tongnao Capsules by Orthogonal Test

Objective: To optimize extraction process of Xifeng Tongnao capsules.Method: With the content of paeoniflorin and yield of extract as indexes,the amount of water,soaking time,extraction time and extraction times were chosen as factors,orthogonal design was used to optimize water extraction process of Radix Paeoniae Rubra and nine other Chinese herbal pieces from Xifeng Tongnao capsules;With yield of extract as index,the amount and concentration of ethanol,soaking time and reflux extraction time were selected as factors,orthogonal design was used to optimize alcohol extraction process of Radix Et Rhizoma Notoginseng from Xifeng Tongnao capsules.Result: Optimum water extraction technology was as following: soaked 0.5 h with 10 times the amount of water,extracted 2 times,1.5 hours per time;Optimum alcohol extraction process was as following: soaked 0.5 h with 6-fold of 70% ethanol,reflux extracted 3 times with extraction time of 1.5,1,1 h.Conclusion: This optimized extraction technology was stable and reliable,it could be extended to large-scale production application of Xifeng Tongnao capsules.