Effect of montelukast on hemorheology and lung function in patients with chronic obstructive pulmonary diseases

Objective To determine the therapeutic effect of hemorheology and lung function with montelukast on patients with chronic obstructive pulmonary diseases(COPD).Methods Sixty patients with COPD from January 2008 to October 2008 were randomly divided into 2 groups:a montelukast group and a control group,30 patients in each group,and 30 healthy persons as healthy control group.The control group received routine treatment.The montelukast(10 mg per night for 4 weeks) group received montelukast and the rountine treatment.The clinical conditions were checked before and after the treatment,including lung function and hemorheology.Results Hemorheology in the montelukast group was significantly decreased than that in the control group after the treatment.The levels of FEV1% and FEV1/FVC(%)were significantly increased in the montelukast group as compared with the control group after the treatment.The difference had statistical significance.Conclusion Montelukast has treatment and prophylactic effect on patients with COPD.