Effects of intensively antihypertensive therapy by Urapidil on hematoma enlargement in patients with hypertensive intracerebral hemorrhage

Objective To investigate the effects of intensively antihypertensive therapy by Urapidil on hematoma enlargement in patients with hypertensive intracerebral hemorrhage(HICH).Methods Hundred and four-six HICH patients were randomly divided into intensively antihypertensive group(intensive group,75 cases,Urapidil was intravenous injected by micro-pump,the target value of mean arterial pressure was 110 mmHg) and the conventional antihypertensive group(control group,71 cases,Captopril was taken,the target value of mean arterial pressure was 130 mmHg).The changes of hematoma volume and score of NIHSS were observed after treatment,as well as mortality and adverse drug reaction.Results Twenty-four h after treatment in intensive group,the average volume of hematoma [(11.9±9.5) ml],the rate of hematoma enlargement(14.7%,11 cases),and the score of NIHSS(7.2±5.0) were significantly differences compared with the control group [(13.2±9.9)ml,(31.0%,22 cases),(8.9±6.8)scores](all P0.05).Thirty d after onset,the score of NIHSS(4.6±3.4) in intensive group was significant lower than control group(5.7±4.1)(P0.01);the mortality rate(5.3%) was lower than control group(9.9%),but the difference was no statistically significant.The adverse reactions between the two groups was no significant different.Conclusion Therapy of Urapidil intensive antihypertension can prevent hematoma enlargement of HICH patients,and the method is safe and reliable.