Different antihypertensive drugs preventing early hematoma expansion in patients with hypertensive cerebral hemorrhage

Objective To determine whether different antihypertensive drugs may have different effects on the hematoma and prognosis of intracerebral hemorrhage (ICH) patients to provide reference for drug choices in the clinical blood pressure control of patients with ICH.Methods Ninety three ICH patients,admitted to our hospital from January 2010 to January 2012,were chosen in our study and divided into nimodipine treatment group,urapidil treatment group and control group.Hematoma volumes of the patients were recorded at admission,24 and 72 hours after admission,respectively.The neurological disability grades of the patients were also recorded at discharge.Results The hematoma expanded in all of the three groups at 24 and 72 hours of admission,but not enjoying difference as compared with that before admission (P＞0.05); the hematoma expansion in the nimodipine group was obviously restricted as compared with that in the urapidil group and control group at 24 and 72 hours of admission (P=0.026,P=0.019; P=0.016,P=0.022).Significant differences on the prognosis in the three groups were noted (P＜0.05); the function recovery in the nimodipine group was significantly better as compared with that in the urapidil group and control group (P＜0.05).Conclusion Nimodipine have better effect on the early hematoma expansion and function recovery of ICH patients as compared with urapidil; nimodipine should be first chosen in clinic. Key words: Hypertensive intracerebral hemorrhage; Nimodipine; Urapidil; Hematoma expansion