Effects of super-early strengthening antihypertensive therapy on basal ganglia intracerebral hemorrhage

Objective To study the effects of super-early strengthening antihypertensive therapy on basal ganglia intracerebral hemorrhage. Methods One hundred and twenty patients with super-early basal ganglia intracerebral hemorrhage were randomly divided into strengthening antihypertensive group and general antihypertensive group,and 60 cases in each group. The antihypertensive agent were used intravenously to reduce the systolic blood pressure to level of 130- 140 mmHg( 1 mmHg = 0. 133 kPa) and 160- 180 mmHg,respectively,within l h after treatment,then maintained for 24 h. Before and after treatment,the National Institutes of Health Stroke Scale( NIHSS) and modified Rankin Scale( mRS) were assessed. Brain CT scanning were performed. The hematoma volume,number of cases of hematoma enlargement and edema volume were measured. The data was statistically compared between groups. Results The NIHSS score of patients in strengthening antihypertensive group was significantly lower than it in general antihypertensive group at 14 days after treatment( P 0. 05). At 90 d after treatment,the proportion of moderate and severe disability assessed by mRS in strengthening antihypertensive group( 25. 0%,15/60) was significantly lower than it in general antihypertensive group( 43. 3%,26/60)( P 0. 05). The hematoma volume and number of cases of hematoma enlargement in strengthening antihypertensive group were significantly less than those in general antihypertensive group at 24 h after treatment( all P 0. 05). The edema volumes in strengthening antihypertensive group were significantly less than those in general antihypertensive group at5 d and 14 d after treatment( all P 0. 05). Conclusions Super-early strengthening antihypertensive therapy could reduce the incidence of hematoma enlargement and the degree of cerebral edema,and improve the neurological function of patients with basal ganglia intracerebral hemorrhage.