Effect of Topiramate on Brain Hippocampus Plasticity of Neurons in Pentylenetetrazol Induced Chronic Epilepsia Rats

Aim: To Study the effect of brain hippocampus plasticity of neurons in the process of occurrence and development of epilepsy and the effect of topiramat(eTPM)on behavior and brain hippocampus plasticity of neurons. Methods: Rats were randomly divided into 3 groups: control group( C group), PTZ group (P group, P1-10 d, P2-20 d and P3-27 d)and TPM+PTZ group(TP group,TP1-10 d, TP2-20 d and TP3-27 d).The behavior and expression of neural cell adhesion molecul(eNCAM) by immunohistochemical staining were observed for 10, 20,27 days after using PTZ. Results: Significant difference in behavior between group P and TP after 4 weeks. Expression of NCAM increased in group P and TP (P0.05), and continuously increased along with time, and the expression in P group is more higher than in group TP at different time-points (P0.05).Conclusion: The increasing of expression of NCAM in hippocampus indicated that plasticity of neurons had occurred and neural plasticity may be an important mechanism of epileptogenesis in the process of PTZ kindling rats. Expression of NCAM was inhibited markedly by TPM, indicating that TPM can influence expression of NCAM and may influence nerve plasticity.