Effects of Oxcarbazapin on the Expression of Nerve Cell Adhesion Molecule in the Hippocampus of Immature Rats with Epilepsy

Objective To explore the effects of oxcarbazapine(OXC)on the expression of NCAM in hippocampus of immature rats with epilepsy.Methods A total of 50 male SD rats around 19 to 21 days of age were randomly allocated into 5 groups:normal saline(NS)group,pentylenetetrazole(PTZ) group,low-dose OXC group(100mg/kg,LDOXC),middle-dose OXC group(200mg/kg,MDOXC)and high-dose OXC group(300mg/kg,HDOXC).The animal model of rats with epilepsy treated by different doses of OXC was established.After twenty-one days administration,changes in behavioral performance were recorded,and the NCAM protein level and mRNA in hippocampus were examined by immunohistochemisty and Real-time PCR respectively.Results Compared with PTZ group,latent time and degree of epileptic seizures induced by PTZ were prolonged and alleviated in OXC groups(P0.01),the expression of NCAM in the astrocyte and NCAM mRNA in hippocampus were depressed in OXC groups(P0.05).Conclusion NCAM may correlate with epilepsy closely.OXC could decrease the expression of NCAM with a dosage dependent manner.OXC may alleviate the brain damage caused by epilepsy.