Immediate Clinical Effects of Administering Dendritic Cells and Cytokine Induced Killer Cells Combined with Chemotherapy in the Treatment of Advanced Non-small Cell Lung Cancer

Objective:To investigate immediate effects and adverse reaction of administering dendritic cells(DC) and cytokine induced killer cells(CIK) combined with chemotherapy in patients with advanced non-small cell lung cancer(NSCLC).Method:According to random number form,62 cases ofⅢ-Ⅳadvanced NSCLC patients were divided two groups randomly:treatment group and control group. The treatment group received DC-CIK combined with NP chemotherapy.The control group received only NP chemotherapy.The size of the tumor,T lymphocyte subtypes in peripheral blood and adverse reaction of the two group patients were analyzed and controlled.Result:The effect effective rate of tumor change of treatment group was 45.16%,showed no significant difference compare with 32.26% of control group.Stability rate of tumor change of treatment group was 83.87%,significant higher than 61.29% of control group(P0.05).The levels of T lymphocyte subtypes of treatment group showed no difference after treatment(P0.05),while the level of CD3+、CD4+ and CD4+/CD8+ decreased compare with before treatment(P0.05).There was no difference of adverse reaction between two group.Conclusion:Compared with control group,using DC-CIK combined with chemotherapy have better immediate clinical effects.It can effective control tumor and elevate cellular immune function of patients.