Effect of antilogous cytokine induced killer cells and dendrite cells combined with chemotherapy on advanced non-small cell lung cancer patients

Objective To observe the clinical effects of autologous cytokine induced killer cells(CIK)and dendritic cells(DC)combined with chemotherapy on advanced non-small cell lung cancer(NSCLC)patients. Methods The 62 non-small lung cancere patients were randomly divided into group A comprised of 31 cases(DC-CIK+NP chemotherapy group)and group B comprised of 31 cases(NP chemotherapy group),by comparing the two groups of patients with lung cancer before and after treatment of clinical curative effect and T lymphocyte subtypes in peripheral blood. Results The effective rate in group A and group B were 29.03% and 19.35%,the response rate were 29.03%and 19.35%,and the disease control rate were 74.19% and.51.60%(P=0.131,P=0.031).The levels of CD3+and CD4+in the group A increasd after treatment,which showed significant statistical difference. Conclusion The use of autologus DC-CIK combined with chemotherapy for treatment advanced NSCLC has advantages of inhibiting the growth of tumor,enhancing immune function and improving the quality of life.