Clinical effects of administering dendritic cells and cytokine induced killer cells combined with chemotherapy in the treatment of advanced non-small cell lung cancer

Objective To investigate immediate effects of administering dendritic cells(DC) and cytokine induced killer cells(CIK) combined with chemotherapy in patients with advanced non-small cell lung cancer(NSCLC).Methods Sixty-four advanced NSCLC patients were divided two groups randomly: a control group and an immunotherapy with chemotherapy group.The treatment group received DC and CIK at an interval of 10~14 days after chemotherapy.The control group only received chemotherapy.T lymphocyte subtypes in peripheral blood of the two group patients were analyzed,Performance Status(KPS) and clinical effects were observed.Side effects were also observed.Results The levels of CD+3、CD+4 in the immunotherapy group increased after treatment,which showed significant statistical difference(P=0.018,P=0.047),while those of the control group had no significant changes.The response rate(RR) was 43.75% in the immunotherapy group,and 34.38% in the control group(P0.05).The RR of KPS was 84.4%in the immunotherapy group,and 62.5% in the control group(P0.05).Conclusion Immunotherapy based DC and CIK with chemotherapy can improve T lymphocyte subtypes in peripheral blood of advanced NSCLC patients,and improve their effects and their quality of life.