Effect of Montelukast on the level of serum IL-4,TNF-α and IFN-γ in children with asthma

Objective: To investigate the effect of Montelukast on serum IL-4,TNF-α and IFN-γ in children with asthma,and to discuss the mechanism of preventing and controlling asthma.Methods: 180 children with acute attack asthma were randomly divided into treatment group and control group,90 cases for the same period check-up children served as the normal group.Based on the basic treatment as control group,the treatment group was also given Montelukast 5 mg/d bedtime orally,1 time per day for half a year.Results: The serum IL-4 and TNF-α of treatment group half a year after treatment were significantly decreased compared with those of the control group,the serum IFN-γ was significantly increased compared with that of control group,and the treatment group was similar with the normal group.Conclusion: Montelukast can reduce IL-4 and TNF-α levels,can increase IFN-γ level in children with asthma,and can also decrease inflammatory reaction,Montelukast can be used to treat asthma effectively.