Influence of Montelukast Combined with Glucocorticoid on Lung Function,Serum IL-4 and IL-25 of Children with Asthma

Objective To observe the influence of leukotriene receptor antagonist montelukast on lung function,interleukin-4(IL-4)and IL-25 of children between 6 to 14 years old with asthma.Methods 80 cases of children between 6 to 14 years old with asthma were randomly divided into two groups with 40 cases separately.The intervention group of inhaled corticosteroids as group A,and the group B were given the leukotriene receptor antagonist montelukast sodium based on group A.The changes of pulmonary function,the serum IL-4 and IL-25 were detected before treatment and 12 weeks after treatment.Results After treatment,the pulmonary functions of the two groups were all improved.Group B had more significant improvement than group A(P0.05).Compared with the results before treatment,serum IL-4 and IL-25 of two groups after treatment decreased significantly,Group B has more significant decrease than group A(P0.05).Conclusion The oral montelukast combined with inhaled corticosteroids could obviously rectify the abnormal changes of inflammatory cytokines IL-4 and IL-25 and can improve lung function of children.