Effect of Combination of Benazepril,Salvia Miltiorrhiza and Spironolactone on Glomerular Filtration Rate in Patients with Diabetic Nephropathy

OBJECTIVE To illustrate the effect of combination of benazepril,spironolactone and Salvia miltiorrhiza on glomerular filtration rate in patients with diabetic nephropathy.METHODS Eighty patients with diabetic nephropathy were randomly divided into 4 groups: control group,group A(benazepril group),group B(benazepril + Salvia miltiorrhiza group),group C(benazepril+spironolactone+Salvia miltiorrhiza group).All patients were treated with hydrochlorothiazide(25 mg·d-1) orally for 4 weeks respectively.Renal histology was examined and blood pressure,plasma glucose,HbAlc,serum creatinine(Scr),urine protein and glomerular filtration rate(GFR) were measured respectively before and after treatment.RESULTS At the initial levels of blood pressure,urine protein,Scr and GFR did not show significant change in 4 groups.After 4 weeks,the levels of urine protein and Scr were much lower in group A,B and C(P0.01) and the levels of GFR was significantly higher(P0.05) than control group.The levels of blood pressure,urine protein and Scr were much lower and the level of GFR after treatment was higher in group B than group A.The levels of blood pressure,urine protein and Scr were decreased(P0.01) and the levels of GFR was increased(P0.05) compared to the levels before treatment in groups C.The levels of blood pressure,urine protein and Scr were much lower and the level of GFR after treatment was higher in group C than in group A(P0.01).After the treatment,the levels of urine protein and Scr were much lower in group C than group B(P0.05),and the levels of GFR were significantly higher(P0.05).CONCLUSION Combination of benazepril,spironolactone and Salvia miltrirrhiza could enhance GFR,decrease urine protein and Scr in the patients with diabetic nephropathy and protect kidney function.