2006•Guoji yiyao weisheng daobaoRequires access

Treatment for Diabetic Nephropathy with Integrated Liposomal Prostaglandin E_1 and Benazepril

Zhou Jin-hui

Abstract

Objective To study the effects of integrated Liposomal prostaglandin E1 (Lipo PGE1) and benazepril on early diabetic nephropathy(DN) and clinical DN.Methods 60 patients of type 2 diabetic patients with DN were randomly divided into control group (benazepril) and treated group (benazepril+Lipo PGE1).UARE,Scr and BUN figures were compared between two groups before treatment and eight weeks after treatment.Results UAER had been decreased significantly in both groups(P0.05,P0.01),and more significantly in treated group than in control group(P0.05),Scr had been decreased significantly in treated group(P0.01).while no significantly decrease of Scr had been found in control group during the follow-up (P0.05).Furtheremore,no significant decrease of BUN, FBG,MPA,TC and TG had been found in both groups.Conclusion Integrated Lipo PGE1 and benazepril can ameliorate protenuria and improve renalfunction of the patients with early DN ang clinical DN of normal renal function.

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Key concepts: Benazepril, Diabetic nephropathy, Medicine, Urology, Renal function, Prostaglandin, Internal medicine, Endocrinology