Effects of Losartan on serum uric acid and glomerular filtration rate in patients with essential hypertension

Objective To investigate the effect of Losartan on serum uric acid(UA) and glomerular filtration rate(GFR) in patients with essential hypertension.Methods 80 patients with essential hypertension were randomly divided into Losartan group(Losartan 50 mg,40 cases) and control group(Benazepril 10 mg,40 cases).Total treatment duration was 8 weeks,serum uric acid levels and renal function were measured before and after treatment,and the glomerular filtration rate was calculated.Results The level of blood pressure of two groups were significantly lower than before treatment(P 0.05),the antihypertensive effect in the two groups were not significant different(P 0.05).After 8 weeks of treatment,serum UA levels of Losartan group were significantly lower than before treatment(P 0.05),and compared with the control group,the difference was significant(P 0.05).After 8 weeks treatment,GFR than those before treatment of all the patients were significantly increased(P 0.05),but there were no significant differences between the two groups(P 0.05).Conclusion Losartan and Benazepril all have a good antihypertensive and renal protective effect,but Losartan can reduce the uric acid.