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2011•Chinese Journal of Modern Drug ApplicationRequires access

Determination of Icariin in Kangguzengsheng capsules by HPLC

Chen Zhong-xi

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Abstract

Objective To establish a HPLC method for determining the icariin content in Kangguzengsheng capsules.Methods HPLC was used to detect Icariin in Kangguzengsheng capsules,with C18column(250 mm×4·6 mm,5μm).The mobile phase consisted of acetonitrile-water(30:70).The flowrate was 1·0 ml/min and column temperature was25℃.The detecting wavelength was at270 nm.Results The method was linear atthe range of0·235 ~1·175 g/ml for Icariin(r =0·9992).The average recovery rate was99· 46%,RSD=1·74%,n=6).Conclusion The method is convenient and accurate,which can be applied to the content determination of Icariin and the quality control of Kangguzengsheng Capsules.

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What this paper is about

Objective To establish a HPLC method for determining the icariin content in Kangguzengsheng capsules.Methods HPLC was used to detect Icariin in Kangguzengsheng capsules,with C18column(250 mm×4·6 mm,5μm).The mobile phase consisted of acetonitrile-water(30:70).The flowrate was 1·0 ml/min and column temperature was25℃.The detecting wavelength was at270 nm.Results The method was linear atthe range of0·235 ~1·175 g/ml for Icariin(r =0·9992).The average recovery rate was99· 46%,RSD=1·74%,n=6).Conclusion The method is convenient and accurate,which can be applied to the content determination of Icariin and the quality control of Kangguzengsheng Capsules.

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Available abstract

Objective To establish a HPLC method for determining the icariin content in Kangguzengsheng capsules.Methods HPLC was used to detect Icariin in Kangguzengsheng capsules,with C18column(250 mm×4·6 mm,5μm).The mobile phase consisted of acetonitrile-water(30:70).The flowrate was 1·0 ml/min and column temperature was25℃.The detecting wavelength was at270 nm.Results The method was linear atthe range of0·235 ~1·175 g/ml for Icariin(r =0·9992).The average recovery rate was99· 46%,RSD=1·74%,n=6).Conclusion The method is convenient and accurate,which can be applied to the content determination of Icariin and the quality control of Kangguzengsheng Capsules.

Key concepts: Icariin, Chromatography, Chemistry, High-performance liquid chromatography, Content determination, Linear range, Linear relationship, Recovery rate

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