Effect of Amlodipine Besylate and Atoravastin on Carotid Arteriosclerosis in Patients With Essential Hypertension

Objective:To explore the effect of amlodipine besylate and atoravastin on carotid artery intima-media thickness ( IMT ) in patients with essential hypertension. Methods: Seventy-nine patients with essential hypertension complicated with carotid arteriosclerosis were randomly divided into control group (39 cases) and experimental group (40 cases). Patients in control group were treated with amlodipine besylate 5mg/d,and the dosage was added to 10mg/d if the blood pressure was above 140/90mmHg after 2 weeks' treatment. Patients in the experimental group were given atoravastin 20mg/d once every night for 28 weeks. The IMT of carotid artery,blood pressure,levels of TC,TG,LDL-C,HDL-C,hs-CRP were monitored before and after treatments. Results: The IMT and blood pressure decreased obviously in two groups 28 weeks after treatment (P0.05),and IMT decreased significantly in experimental group compared with that of control group (P0.05). Level of TG,TC,LDL-C and hs-CRP decreased,and HDL-C increased significantly in experimental group than those in control group and before treatment (P0.05). Conclusions: Combined application of Amlodipine besylate and atoravastin has significant effect on IMT of carotid artery in patients with essential hypertension,and it can delay the progression of essential hypertension.