Expression and significance of KISS-1,Cath-D and VEGF in breast cancer tissues

Objective:To study the expression of KISS-1、Cath-D and VEGF in breast cancer tissues and the characteristics in clinical pathological findings for investigating the mechanisms of the three factors in the development of breast cancer.Methods:Immunohistochemical technique(S-P method)was used to detect the expression of KISS-1,Cath-D and VEGF in each of the 50 breast cancer cases as well as normal tissues 3 cm off the tumor region.Results:①The positive expression rate of KISS-1 in breast carcinomas was significantly lower than that in normal breast tissues(P0.01),whereas the positive expression rate of Cath-D,VEGF in breast carcinomas was significantly higher than that in normal breast tissues(P0.01).②The positive percentage of KISS-1 in breast cancers with metastasis in lymph node was lower than that of absence of metastasis in lymph node(P0.05),but the positive percentage of Cath-D,VEGF in breast cancers with metastasis in lymph node was higher than that of absence of metastasis in lymph node(P0.05).③The expression of KISS-1,Cath-D and VEGF in breast tumor tissues showed a significant negative correlation.Conclusion:The expression of KISS-1 gene may play important role in inhibiting metastasis of breast cancer,Loss of KiSS-1 gene expression that leads to the invasion and metastasis of breast cancer may participate in the lymphnode metastasis and the formation of cancer vessels.