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2014•Immunological JournalRequires access

The expression of Foxp3 and TGF-β1 in pterygium

Liu Yuan-bi

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Abstract

To study the roles of Foxp3 and TGF-β1 played in pathogenesis of human pterygium,we used immunohistochemistry and ELISA technique to investigate the expression difference of Foxp3 and TGF-β1 between human pterygium and the normal conjunctiva tissue.The results showed that the expression levels of Foxp3 and TGF-β1 in pterygium were stronger than those in the normal conjunctiva tissue(P 0.05),and Foxp3 and TGF-β1levels were positively correlated in pterygium(r=0.614,P 0.05),suggesting over-expression of Foxp3 and TGF-β1may play an important role in the pathogenesis of pterygium.

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What this paper is about

To study the roles of Foxp3 and TGF-β1 played in pathogenesis of human pterygium,we used immunohistochemistry and ELISA technique to investigate the expression difference of Foxp3 and TGF-β1 between human pterygium and the normal conjunctiva tissue.The results showed that the expression levels of Foxp3 and TGF-β1 in pterygium were stronger than those in the normal conjunctiva tissue(P 0.05),and Foxp3 and TGF-β1levels were positively correlated in pterygium(r=0.614,P 0.05),suggesting over-expression of Foxp3 and TGF-β1may play an important role in the pathogenesis of pterygium.

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Available abstract

To study the roles of Foxp3 and TGF-β1 played in pathogenesis of human pterygium,we used immunohistochemistry and ELISA technique to investigate the expression difference of Foxp3 and TGF-β1 between human pterygium and the normal conjunctiva tissue.The results showed that the expression levels of Foxp3 and TGF-β1 in pterygium were stronger than those in the normal conjunctiva tissue(P 0.05),and Foxp3 and TGF-β1levels were positively correlated in pterygium(r=0.614,P 0.05),suggesting over-expression of Foxp3 and TGF-β1may play an important role in the pathogenesis of pterygium.

Key concepts: Pterygium, Pathogenesis, Conjunctiva, FOXP3, Immunohistochemistry, Transforming growth factor, Pathology, Medicine

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