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The clinical significance of serum soluble CD40L level in coronary heart disease

Jichang Zhang

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Abstract

Objective To investigate the clinical significance of the serum level of soluble CD40 ligand(sCD40L) in acute coronary syndrome. Method Enzyme-linked immunosorbent assay (EIA) was used to measure sCD40L in 60 patients with acute coronary syndrome (48 with unstable angina pectoris and 12 with acute myocardial infarction) and 60 matched healthy controls. Results sCD40L level was significantly higher in patients with acute coronary syndrome (ACS) than that of controls (P0.01), and significantly higher in patients with acute myocardial infarction than that of those with unstable angina pectoris (P0.05). Incidence of high risk of cardiovascular event during follow - up period was higher in patients with high sCD40L level than that of those with normal sCD40L level. Conclusion The levels of sCD40L increase in acute coronary syndrome , which may be related to the pathogenesis of ACS, can be used as a potential marker of plaque instability.

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Objective To investigate the clinical significance of the serum level of soluble CD40 ligand(sCD40L) in acute coronary syndrome. Method Enzyme-linked immunosorbent assay (EIA) was used to measure sCD40L in 60 patients with acute coronary syndrome (48 with unstable angina pectoris and 12 with acute myocardial infarction) and 60 matched healthy controls. Results sCD40L level was significantly higher in patients with acute coronary syndrome (ACS) than that of controls (P0.01), and significantly higher in patients with acute myocardial infarction than that of those with unstable angina pectoris (P0.05). Incidence of high risk of cardiovascular event during follow - up period was higher in patients with high sCD40L level than that of those with normal sCD40L level. Conclusion The levels of sCD40L increase in acute coronary syndrome , which may be related to the pathogenesis of ACS, can be used as a potential marker of plaque instability.

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Available abstract

Objective To investigate the clinical significance of the serum level of soluble CD40 ligand(sCD40L) in acute coronary syndrome. Method Enzyme-linked immunosorbent assay (EIA) was used to measure sCD40L in 60 patients with acute coronary syndrome (48 with unstable angina pectoris and 12 with acute myocardial infarction) and 60 matched healthy controls. Results sCD40L level was significantly higher in patients with acute coronary syndrome (ACS) than that of controls (P0.01), and significantly higher in patients with acute myocardial infarction than that of those with unstable angina pectoris (P0.05). Incidence of high risk of cardiovascular event during follow - up period was higher in patients with high sCD40L level than that of those with normal sCD40L level. Conclusion The levels of sCD40L increase in acute coronary syndrome , which may be related to the pathogenesis of ACS, can be used as a potential marker of plaque instability.

Key concepts: Medicine, Unstable angina, Acute coronary syndrome, Myocardial infarction, Internal medicine, Cardiology, Pathogenesis, Clinical significance

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