The Protective Effects of Edaravone Combined with Xuebijing on Lung Injury after Intestinal Obstruction Surgery of Rabbits

Objective To investigate the effects of edaravone and Xuebijing on the lung injury after intestinal obstruction surgery in rabbits and to explore the probably mechanism. Methods Thirty- six healthy adult rabbits were randomly divided into three groups: normal control group( group C),model group( group M) and edaravone combined with Xuebijing group( group EX),each group with 12 rabbits. Hone mechanical model of thecompleteintestinalobstructionwereestablishedwithreferencetothemethodofLilinect,)Resectionoftheileocecaljunctionoftherabbitwasperformedafter24hours.Edaravonecombining with Xuebijing were given in group EX,while normal saline were given in group C and group M. After operation 24 h rabbits were executed,dry / wet weight( D / W) ratio of lung was counted and malondialdehyde( MDA) content,superoxide( SOD) activity,glutathione peroxidase( GSH- PX) activity in serum and lung were detected,respectively. In addition,the levels of tumor necrosis factor- α( TNF- α),interleukin- 1( IL-1),hea proteint shock 70( HPS70) of serum were determined. Results The MDA content of serum and lung and the level of TNF- α,IL- 1 in group M were significantly higher than those in group C and group EX( P 0. 05). However,D/W ratio of lung,SOD activity,GSH- PX activity of serum and lung,HPS70 of serum in group M were significantly lower than those in group C and group EX( P 0. 05). Conclusion Edaravone combined with Xuebijing can alleviate lung injury after intestinal obstruction surgery by inhibiting inflammatory mediators to relieve lung damage from oxygen free radicals which are generated by intestinal ischemia reperfusion.