Human papilloma virus infections in patients with breast infiltrating ductal carcinoma

OBJECTIVE To observe the status of different pathological high-risk human papilloma virus(HPV)HPV 18and HPV 16infections in patients with breast invasive ductal carcinoma and explore the correlation between the HPV18and HPV16infections and the formation and transformation of invasive ductal breast cancer so as to provide a theoretical basis for the diagnosis and treatment of breast cancer.METHODS The submitted specimens of 128cases of female breast cancer patient were randomly collected from Jan 2007to Jan 2012,and were divided into the observation group(98cases)and the control group(30cases),the patients with breast invasive ductal carcinoma were assigned in the observation group,the infiltrating ductal cancer patients with normal breast tissues as the control group.The expression of HPV18and HPV16was detected by in situ hybridization method.RESULTS The positive rates of expression of the HPV18molecules,HPV16molecules,and HPV18and HPV16molecules were respectively 66.33%,71.43% and 52.04% in the infiltrating ductal carcinoma tissues,which were respectively 16.67%,23.33%,and 10.00%in the normal breast epithelial tissue,the difference was significant(P0.05);In addition,the positive expression rates of the three types of viruses in the patients with invasive ductal carcinoma were respectively 43.48%,47.83% and 17.39%in the stageⅠ,60.00%,63.33% and50.00%in the stageⅡ,77.42%,83.87%and 67.74%in the stageⅢ,92.86%,100.00% and 78.57%in the stageⅣ.The difference in the positive expression rate of the three kinds of viruses between the stageⅠand other three stages was significant(P0.05).With the deterioration of the condition of cancer,the expression rate of HPV18and HPV16molecules was increased,and there was a positive correlation between the transformation and the expression of HPV18and HPV16molecules(r=0.6834,P0.05).CONCLUSION There is a correlation between the HPV18and HPV16infections and the formation and transformation of breast infiltrating ductal carcinoma;along with the deterioration of breast cancer,the expression rate of HPV18and HPV16is increased,the finding can provide a new therapeutic approach for the treatment of breast cancer.