Expression of p53 and significance of HPV 16/18 infection in invasive ductal carcinoma

Objective To study the infection of human papillomavirus(HPV) 16/18 and its relationship with expression of p53 in invasive ductal carcinoma.Methods The expression of HPV16/18 DNA and p53 in the invasive ductal carcinoma(n=45),breast fibroadenoma(n=20) and normal breast tissue(n=20) were detected with immunohistochemistry method and polymerase chain reaction.Results The expression rate of HPV 16/18 DNA and p53 protein in invasive ductal carcinoma(51.1% and 46.7%) were significantly higher than those of in fibroadenoma of breast(15.0% and 10.0%) and normal breast tissue(5.0% and 0%,P0.01),and the expression rate in patients with axillary lymphnode metastasis was significantly higher than those without axillary lymphnode metastasis(P0.05).The expression rate of p53 protein increased with TMN staging and there was a positive correlation between HPV 16/18 DNA and p53 protein expression(χ2=6.517,P0.05).Conclusion Both HPV 16/18 infection and p53 mutation are involved in the occurrence and progress of breast carcinoma and HPV 16/18 infection may be the main factor relative to p53 mutation.