The Expression and Correlation Studies of HPV16/18 Infection and p53 in Female with Breast Infiltrating Ductal Carcinoma

Objective To explore the expression and their relationship of HPV16/18 infection and p53 in female with breast infiltrating ductal carcinoma.Methods The expression level of HPV16/18 DNA and p53 in women breast infiltrating ductal carcinoma(n=45),breast fibroadenoma(n=20) and normal breast tissue(n=20) were detected with immunohistochemistry methods and PCR technology,respectively.Results HPV16/18 DNA and p53 protein expression rate in breast cancer group(51.1% and 46.7%) were obviously higher than those in fibroadenoma group(15.0% and 10.0%) and normal breast group(5.0% and 0%)(P0.01),and the expression rate of HPV16/18 DNA and p53 protein in the axillary lymph node metastasis was obviously higher than those without the axillary lymph node metastasis(P0.05).With the increase of TMN,the expression rate of P53 protein increased significantly(P0.05),HPV16/18 DNA and p53 protein expression was obviously positive correlated(rs=0.614,P0.05).Conclusion HPV infection and p53 mutations participate jointly in the occurrence and development of female breast cancer,HPV infection may be the important factor for promoting p53 mutations.