2009•Lishizhen Medicine and Materia Medica ResearchRequires access
Effect of Pulse-activating Injection on the Expression of Nuclear Factor-kappa B and iNOS in Lung Tissue of Acute Paraquat Poisoned Rats
Wei Fang
Open publisher page 4 citations
Abstract
Objective To invesigate the protective effect of pulse-activating injection against rat acute lung injury.Methods 50 Sprague-Dawley(SD) rats were randomly divided into five experimental groups: blank group,negative control group,positive control group,Pulse-activating injection low dose group(LDG),Pulse-activating injection high dose group(HDG).Macroscopic and histopathological examinations were performed,and the activities of lung tissue homogenate NK-кB and iNOS were measured.ResultsCompared with negative control group,and biological indexes of lung injury and the contents of NK-кB and iNOS were significantly decreased in pulse-activating injection groups(P0.05,P0.01).ConclusionNK-кB and iNOS play important roles in lung injury of poisoned rats.Pulse-activating injection can ameliorate the lung injury and decrease the levels of NK-кB and iNOS.