Association of the Genotype and Serum Level of P-Selectin with Acute Myocardial Infarction

Aim To investigate the association of P-selectin gene single nucleotide polymorphisms(SNP) and susceptibility to acute myocardial infarction(AMI) in a Chinese population,and to analyze association of serum levels and genotypes of P-selectin with AMI. Methods P-selectin gene-2123 G/C single nucleotide polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) and DNA sequencing among 150 AMI patients and 160 age and sex matched controls in a Chinese population,and serum level of P-selectin was determined by enzyme-linked immunosorbent assay(ELISA). Results Serum levels of P-selectin in AMI patients were significantly higher than those of controls(P0.05),the distributions of P-selectin gene-2123 G/C polymorphism were significantly different between AMI group and control group(P0.05). The relative risk suffered from AMI of-2123 C allele was 1.625 times of the G allele carriers(OR=1.625,95%CI was 1.177～2.244,P=0.003);the serum levels of P-selectin C allele carriers was significantly higher than no carriers(P0.05). Conclusions P-selectin gene-2123 G/C polymorphism was associated with AMI,-2123 C allele is an important genetic susceptibility gene for AMI. In which the P-selectin C allele carriers may increase risk by enhancing the P-selectin expression in the pathogenesis of AMI.