Study on sedative and hyponotic effect of total alkaloidfrom Semen Zizyphi Spinosae

Objective: In this paper the sedative and hyponotic effects of total alkaloids were studied. Methods: sedative and hyponotic as well as anticonvulsant experiments were made to observe the effect of total alkaloid from semen zizyphi spinosae on the spontaneous motion and hyponosis in mice. Results: The result showed that total alkaloid from Semen Zizyphi Spinosae could markedly inhibit spontaneous motion,enhance the sleeping number of pentobarbital sodium (subthreshold dosage; and prolong the sleeping time of pentobarbital sodium (superthreshold dosage;. Conclusion: The total alkaloid from Semen Zizyphi Spinosae possesses obvious sedative and hyponotic effects.