Distribution and drug resistance of pathogens in urinary tract infection

[Objective] To study the distribution and drug resistance characteristic of pathogens in urinary tract infection and provide basis for clinicians to select antibiotics correctly. [Methods] Identification and susceptibility test of 611 isolates from urine specimens were performed by TDR system and K-B method. the statistical analysis was performed by SPSS software. [Results] Among 611 isolates, gram-negative bacilli and gram-positive cocci accounted for 52.5%(321/611) and 42.6%(260/611) respectively. Corynebacterium and fungi accounted for 4.9%(30/611).The most common pathogens were Escherichia coli, accounting for 34.2%(209), followed by Enterococcus faecalis (17.5%, 107) , coagulase negative Staphylococcus (CONS)(11.5%,70), Klebsiella pneumoniae (6.4%,39), Enterococcus faecium (4.3%,26). the gram-negative bacilli were most sensitive to Meropenem and the resistance rate were 0%～5.9%. and the resistant rate to trimethoprim-sulfamethoxazole and ampicillin were 51.3%～76.9%and 46.7%～83.6%, respectively. Among gram-positive cocci, the Staphylococcus were still sensitive to vancomycin (100%), but the resistant rate to oxacillin were reached to 50%. High resistant rates to six antibiotics ( 79.4%~94.4%) were observed among Enterococcus faecalis. Resistant rates of the Staphylococcus epidermidis to four antibiotics was 74.0%~94.0%. Both gram-negative bacilli and gram-positive cocci were still sensitve to NIT (nitrofurantoin) and resistant rates were 0%~20.5%. [Conclusion] Escherichia coli ,Enterococcus faecalis and coagulase negative Staphylococcus (CONS) were main pathogens in urinary tract infection. The resistance rate of pathogens to different antibiotics were different. Rational use of antibiotics should be carried out according to the distribution characteristic of pathogens in urinary tract infection and Microbial sensitivity test results.