Analysis of results in detection of pathogen in urinary tract

Objective To analyze the distribution and features of drug resistance pathogens in urinary tract infection and provide basis for clinical use of antibiotics correctly.Methods The 285 bacterial strains isolated from urine samples between January 2005 and December 2006 in Affiliated Hospital of Hainan Medical College were identified and their resistance to antibiotics were tested.Results Among the 285 isolates,there were 148 strains of gram-negative bacilli(51.9%),108 strains of gram-positive cocci(37.9%)and 29 strains of corynebacterium and fungi(10.2%).The most common pathogens were Escherichia coli,accounting for 35.8%,followed by Enterococcus faecalis 18.2%,coagulase negative Staphylococcus(CONS)9.5%,fungi 6.3%.the gram-negative and gram-positive bacilli were most sensitive to nitrofurantoin.and the resistant rate to trimethoprim-sulfamethoxazole and ampicillin were more then 50%.Among gram-positive cocci,the Staphylococcus were still sensitive to meropenem and vancomycin,but gram-negative cocci were also sensitive to meropenem and quinolones.Conclusion Escherichia coli,Enterococcus faecalis and coagulase negative Staphylococcus(CONS)were main pathogens in urinary tract infection.The resistance rate of pathogens to different antibiotics were different.Rational use of antibiotica should be carried out according to the distribution characteristic of pathogens in urinary tract infection and Microbial sensitivity test results.