Distribution and Drug Resistance of Pathogens in Urinary Tract Infection

Objective To investigate the bacterial distribution and antibiotic resistance situation with urinary tract infection(UTI) for providing the evidence for rational use of antibiotics in clinic. Methods Identification and susceptibility test of 216 isolates from urine specimens were performed by TDR system and K-B method.In addition,ESBLs were also detected in gram-negative bacilli. Results Among 216 strains,gram-negative bacilli,gram-positive cocci,and fungi accounted for 65.3%(141/216),30.1%(65/216),and 4.6%(10/216) respectively.The gram-negative bacilli were the most sensitive to imipenem and the resistance rate was between 0% and 12.5%,the resistant rates to piperacillin and gentamicin were 60.3%～66.6% and 50.0%～70.3%,respectively.Among gram-positive cocci,all the Staphylococci were sensitive to vancomycin(100%),but 53.3% of them were resistant to oxacillin.Enterococci were highly resistant(26.3%～47.4%) to common antimicrobial drugs and one was resistant(5.3%) to vancomycin.29.8 % of Escherichia coli and 21.0% of Klebsiella pneumoniae isolates produced ESBLs. Conclusions Gram-negative bacilli are the predominant organism in urinary tract infections in The Third Hospital of Changsha.The high antibiotic resistance of commonly encountered pathogens is a serious problem and much attention should be paid to detect pathogens and their antibiotic resistance.