Ureaplasma urealyticuminfections in patients with non-gonococcal urethritis and drug susceptibility testing

OBJECTIVE To investigate the status of Ureaplasma urealyticum(Uu) infections in the patients with non-gonococcal urethritis(NGU) and analyze its drug resistance so as to provide basis for the rational use of antibiotics.METHODS A total of 632 cases of suspected NGU patients were enrolled in the study,the urethral discharge of the male patients and cervical secretions from the female patients were sampled for the culture of Uu,the drug susceptibility testing was performed,then the positive rate and the susceptibility of the Uu were observed.RESULTS Of 632 suspected NGU patients including 2675 males and 367 females,totally 369 strains of Uu were detected with the positive rate of 58.39%.The positive rate of Uu was 46.42%(123 strains) in the male patients,67.03%(246 strains) in the female patients.The positive rate of the Uu was significantly higher in the female patients than in the male patients,the difference was statistically significant(P0.01).The drug susceptibility of Uu to nine common antimicrobial agents,from high to low,were as follows:pristinamycin,josamycin,doxycycline,azithromycin,clarithromycin,erythromycin,tetracycline,ofloxacin,and cyclopropane gatifloxacin.CONCLUSION Uu is the main species of pathogens causing NGU,there is difference in the Uu infection between the genders.It is necessary for the clinical laboratory personnel to carry out the dynamic monitoring and drug susceptibility testing for Uu infection so as to improve the cure rate of NGU and reduce the emergence of drug resistant strains.