Clinical study on "Bushen Zhuanggu Decoction" combined glucosamine hydrochloride for knee osteoarthritis

Objective To explore the clinical efficacy and safety of Bushen Zhuanggu Decoction combined glucosamine hydrochloride in the treatment of knee osteoarthritis.Methods Ninety cases were randomized into two groups: treatment group in which 45 cases were treated by combination of Bushen Zhuanggu Decoctiononce a day with glucosamine hydrochloride 0.75 g,twice a day orally.Control group in which 45 cases were treated by glucosamine hydrochloride 0.75 g,twice a day orally,with the course of 6 weeks.The clinical efficacy was evaluated by Lequesne index and VAS score,and the adverse reaction was recorded at any time.Results Forty-two cases in treatment group and 41 cases in control group were finished the experiment.In treatment group,there were significant differences in scores of pain,mobility,daily activities and Lequesne between before and after treatment(P0.05);in control group,the scores of pain and Lequesne were different significantly between before and after treatment(P0.05).After treatment,there were significant differences in the four indexes between the two groups(P0.05).In both of the two groups,there were significant differences in VAS scores between before and after treatment(P0.05);after treatment,there were significant differences between the two groups(P0.05).No severe adverse reaction was appeared in both of the groups.Conclusion Bushen Zhuanggu Decoction combined glucosamine hydrochloride is more effective than glucosamine hydrochloride in improving the scores of VAS,Lequesne and pain,especially in mobility and daily activities.