Clinical observation of multiple low doses of nedaplatin(NDP) combined with continuous intravenous infusion of 5-fluorouracil(5-FU) in the treatment of advanced esophageal cancer

Objective:To observe the short-term efficacy and adverse reaction of multiple low dose of nedaplatin(NDP) combined with continuous intravenous infusion of 5-fluorouracil(5-FU) in the treatment of advanced esophageal cancer.Methods: Fifty-five patients with advanced esophageal cancer were divided into experimental group and control group randomly.The experimental group,with 28 cases,was given NDP 20 mg/m2,intravenous drip,d1-5,5-FU 1.5/m2,continuous infusion for 120 hours,with chemotherapy pump;the control group with 27 cases was given NDP 100mg/m2,intravenous drip,d1,the usage of 5-FU was the same as the experimental group.Both 5-FU groups were treated every 21 days as a cycle.Results: The total effective rate of the experimental group was(46.4%),the control group was(51.9%),there was no significant difference between two groups(P 0.05).The rate of myelosuppression of the experimental group was lower than that in the control group,the difference was significant(P0.05),the rates of alimentary canal toxicity and nephrotoxicity had no significant differences between the two groups.Conclusion: Multiple low doses of nedaplatin(NDP) combined with continuous intravenous infusion of 5-fluorouracil(5-FU) in the treatment of advanced esophageal cancer is effective,myelosuppression and gastrointestinal reaction are mild,patients can tolerate it well.Multiple low doses of nedaplatin can be considered to replace the normal usage of nedaplatin(NDP).