Clinical observation of nedaplatin plus 5-fluorouracil in treatment of cisplatin-resistant advanced esophageal cancer

Aim To evaluate efficacy and toxic reactions of nedaplatin plus 5-fluorouracil(5-Fu) in treatment of cisplatin-resistant advanced esophageal cancer.Methods Nedaplatin was administered at a dose of 80 mg·m-2 by drip infusion in 2 hours on day 1.Calcium folinate(CF) with a dose of 75 mg·m-2 was intravenous infused in 2 hours,followed by more than 6h continual intravenous infusion of 5-Fu with a dose of 500 mg·m-2 on d1to d5.Chemotherapy was repeatedly given every 28 days and the efficacy was evaluated by the standard of WHO after 2 to 3 cycles of administration.Results The overall response rate(CR+PR) was 42.4%.One-year survival rate was 29.1%.The major toxicity was myelosuppression.Conclusion Nedaplatin plus 5-Fu is rather active in treating cisplatin-resistant advanced esophageal cancer with acceptable tolerance,and it deserves further popularization.