Clinical Observation of the Therapeutic Effect of Different Dose Simvastatin on Patients with Angina

Objective To explore the theraputic effect of different dose simvastatin on patients with angina.Methods Ninety six patients with angina selected were randomly divided into 3 groups;Control group (n=30)treated with Nitrate,Low Molecular Heparin 、Aspirin etc;Simvastatin A group (n=33) added with simvastatin 20 mg/d on the bases of common treatment mentioned above;Simvastatin B group (n=33) with Simvastatin 40 mg/d;All groups were observed for 8 weeks.The serum levels of lipid and C-reactive protein (CRP) were measured before treated and after 8 weeks respectively.Results The blood lipid levels of the control group were not different statistically before and after treated (P0.05).The difference between the results of Simvastatin A and B groups before and after treated were significant (P0.05),and(P0.05).The difference between the results of simvastatin A and B groups after treated was also significant.Conclusion Simvastatin is beneficial to patients with angina by modulating lipids and attenuating inflammation.