The different-dose simvastatin's effect on the platelet activity after the elderly patients' treatment by PCI

Objective To observe the serum level of the CD62p,CD63 which indicates the platelet activity of the elderly patients treated by different-dose simvastatin after PCI.Methods Sixty-eight patients with acute coronary syndrome post PCI were randomly divided into 20 mg/d simvastatin group(36 patients)and 40 mg/d simvastatin group(32 patients).We examined the patient's blood CD62p,CD63 levels on the day before the treatment of PCI in both groups.Then all of the patients in both groups received different-dose simvastatin treatment(20mg/d or 40 mg/d qn po);we observed the results again after four weeks in both groups,and compared the results.Results The patients' blood CD62p,CD63 levels decreased significantly after the treatment of simvastatin in both groups(P0.01).The CD62p level in 40 mg/d group decreased significantly after the treatment compared with that in 20 mg/d group(P0.05).Conclusion Simvastatin can inhibit the patients' platelet activity after the treatment by PCI.The effect of treatment is better in 40 mg/d simvastatin group than 20 mg/d simvastatin group.