2004•Biaoji mianyi fenxi yu linchuangRequires access

The Clinical Value of Four Serum Makers of Hepatic Fibrosis to Chronic Hepatitis and Cirrhosis

Xilun Gan

Abstract

To study the levels of serum procollagen type Ⅲ(PCⅢ), hyaluronic acid(HA), collagen type Ⅳ (C-Ⅳ) and laminin(LN) and thier clinical significance in the diagnosis and prognostic assessment of chronic hepatitis and cirrhosis, these four marks were measured by RIA in 52 patients with chronic hepatitis and cirrhosis and 42 volunteers(as control) and 38 patients treated with antifibrosis.The levels of four marks in 52 patients were much higher than those in control group(P0.05). The levels of four marks in 38 patients treated with antifibrosis were lower than those before treatment(P0.05).The levels of PCⅢ, HA, C-Ⅳ and LN are of value in diagnosing and assessing prognosis of chronic hepatitis and cirrhosis.

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Key concepts: Medicine, Cirrhosis, Procollagen peptidase, Chronic hepatitis, Gastroenterology, Internal medicine, Hyaluronic acid, Hepatitis