Application of Combined Examine Methods of Hepatic Fibrosis and Serum Marker in Diagnosis of Liver Diseases

Objective: To examine the hepatic fibrosis serum marker levels of Laminin (LN), Precollagen typeⅢ (pcⅢ), Collagen type Ⅳ (CⅣ) and Hyalurohic acid (HA) in different clinical types of hepatitis and other liver and gall diseases and so as to explore their clinical value in diagnosis. Methods: Serum samples of 129 cases of different clinical types of liver disease were collected and the contents of LN, PcⅢ, CⅣ, and HA in them were examined with radiate immune method. The results were compared with those of 30 healthy persons. Results: Significant differences of the contents of the 4 targets were found between each liver disease group and the control. The highest levels were found in serious chronic hepatitis and hepatic fibrosis groups, and there were remarkable differences between them and control gronp (P0.01). Conclusion:It has high clinical value to use combined examination of LN, PCⅢ, CⅣ, and HA in diagnosis of hepatic fibrosis and other hepatic diseases.