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2006•Journal of Public Health and Preventive MedicineRequires access

Genotoxicity of Gaseous Formaldehyde on Brain Cells of Mice

Lou Xiao-hua

Open publisher page 1 citations

Abstract

Objective To explore the DNA damage of brain cells of mice after formaldehyde exposure.(Methods)The mice were treated with gaseous formaldehyde at different concentrations(0.5 mg/m~3,1.0 mg/m~3 and 3.0 mg/m~3) for 72 hours.Single cell gel electrophoresis technique(comet assay) was used to test the DNA damage of the brain cells.(Results) Formaldehyde caused significant DNA strand-break at the concentration of 0.5 and 1.0 mg/m~3,while crosslinks were induced at 3.0 mg/m~3.Conclusion Formaldehyde was both a DNA strand-breaker and a crosslink-agent to the brain in vivo.

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Objective To explore the DNA damage of brain cells of mice after formaldehyde exposure.(Methods)The mice were treated with gaseous formaldehyde at different concentrations(0.5 mg/m~3,1.0 mg/m~3 and 3.0 mg/m~3) for 72 hours.Single cell gel electrophoresis technique(comet assay) was used to test the DNA damage of the brain cells.(Results) Formaldehyde caused significant DNA strand-break at the concentration of 0.5 and 1.0 mg/m~3,while crosslinks were induced at 3.0 mg/m~3.Conclusion Formaldehyde was both a DNA strand-breaker and a crosslink-agent to the brain in vivo.

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Available abstract

Objective To explore the DNA damage of brain cells of mice after formaldehyde exposure.(Methods)The mice were treated with gaseous formaldehyde at different concentrations(0.5 mg/m~3,1.0 mg/m~3 and 3.0 mg/m~3) for 72 hours.Single cell gel electrophoresis technique(comet assay) was used to test the DNA damage of the brain cells.(Results) Formaldehyde caused significant DNA strand-break at the concentration of 0.5 and 1.0 mg/m~3,while crosslinks were induced at 3.0 mg/m~3.Conclusion Formaldehyde was both a DNA strand-breaker and a crosslink-agent to the brain in vivo.

Key concepts: Formaldehyde, Genotoxicity, Comet assay, DNA damage, In vivo, DNA, Gel electrophoresis, Chemistry

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