Gaseous Formaldehyde-Induced DNA-Protein Crosslinks in Mouse Bone Marrow Cells

In order to study the genotoxicity of gaseous formaldehyde(FA)on mouse bone marrow cells,SPF level Kunming male mice were exposed to gaseous formaldehyde for 72h.KCl-SDS assay were applied to detect DNA-protein crosslinks(DPC)in bone marrow cells.Results showed that low concentration(0.5mg·m-3)gaseous formaldehyde could induce DPC formation significantly(compared with the control,p0.05),and high concentrations(1.0,3.0mg·m-3)could induce DPC formation very significantly(p 0.01).DPC was increased with the increasing of gaseous formaldehyde concentrations(0.5,1.0,3.0mg·m-3).The results suggested that among the concentrations investigated in the present study,gaseous formaldehyde had obvious genetic toxicity on the mouse bone marrow cells.