ScholarLens Back to search
2008•Journal of Public Health and Preventive MedicineRequires access

Genotoxicity of liquid formaldehyde on brain cells of goldfish

Xuan Yang

Open publisher page 0 citations

Abstract

Objective To explore the DNA damage of brain cells of goldfish after formaldehyde exposure.Methods The goldfish were treated with liquid formaldehyde at different concentrations(10 μmol/L,100 μmol/L and 1 000 μmol/L) for three days.Single cell gelelectropho resis technique(comet assay) was used to test the DNA damage of the brain cells.Results Formaldehyde caused significant DNA strand break at the concentration of 10 μmol/L,100 μmol/L and 1 000 μmol/L.Conclusion Formaldehyde was a DNA strand breaker,when the concentration is higher,it may cause crosslinkagent to the brain invivo.

About this research paper

What this paper is about

Objective To explore the DNA damage of brain cells of goldfish after formaldehyde exposure.Methods The goldfish were treated with liquid formaldehyde at different concentrations(10 μmol/L,100 μmol/L and 1 000 μmol/L) for three days.Single cell gelelectropho resis technique(comet assay) was used to test the DNA damage of the brain cells.Results Formaldehyde caused significant DNA strand break at the concentration of 10 μmol/L,100 μmol/L and 1 000 μmol/L.Conclusion Formaldehyde was a DNA strand breaker,when the concentration is higher,it may cause crosslinkagent to the brain invivo.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To explore the DNA damage of brain cells of goldfish after formaldehyde exposure.Methods The goldfish were treated with liquid formaldehyde at different concentrations(10 μmol/L,100 μmol/L and 1 000 μmol/L) for three days.Single cell gelelectropho resis technique(comet assay) was used to test the DNA damage of the brain cells.Results Formaldehyde caused significant DNA strand break at the concentration of 10 μmol/L,100 μmol/L and 1 000 μmol/L.Conclusion Formaldehyde was a DNA strand breaker,when the concentration is higher,it may cause crosslinkagent to the brain invivo.

Key concepts: Formaldehyde, Genotoxicity, Comet assay, DNA damage, DNA, Chemistry, Molecular biology, In vivo

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Genotoxicity of liquid formaldehyde on brain cells of goldfish — Research Paper | ScholarLens